Day: March 4, 2023

Climate activists splashed a dark liquid over an artwork Saturday near the German parliament building. Desecrating the art, engraved with key articles from the country’s constitution, drew condemnation from the speaker of parliament and other lawmakers.

The Last Generation group said supporters symbolically “soaked in ‘oil’” the outdoor installation — a series of glass plates on which 19 articles from the German Constitution setting out fundamental rights are engraved. They pasted posters over the work that read, “Oil or fundamental rights?”

The group said in a statement that “the German government is not protecting our fundamental rights” and argued that continuing to burn oil is incompatible with doing so.

Parliament Speaker Barbel Bas said she was appalled by the action and has “no understanding for it.” She said the work by Israeli artist Dani Karavan, titled “Grundgesetz 49” after the German name of the post-World War II constitution and the year when it was drawn up, is a reminder to respect and protect rights such as freedom of expression and assembly.

“Those are the fundamental rights on which the demonstrators from Last Generation themselves base the justification for their actions,” Bas said in a statement. “I can only hope that the glass plates of the artwork were not permanently damaged.”

The work was wiped clean by Saturday afternoon. Last Generation has repeatedly drawn attention and anger over the past year with actions that have included blocking major roads and throwing food at famous paintings.

Source: Voice of America

Drugs known as statins are the first-choice treatment for high cholesterol but millions of people who can’t or won’t take those pills because of side effects may have another option.

In a major study, a different kind of cholesterol-lowering drug named Nexletol reduced the risk of heart attacks and some other cardiovascular problems in people who can’t tolerate statins, researchers reported Saturday.

Doctors already prescribe the drug, known chemically as bempedoic acid, to be used together with a statin to help certain high-risk patients further lower their cholesterol. The new study tested Nexletol without the statin combination — and offers the first evidence that it also reduces the risk of cholesterol-caused health problems.

Statins remain “the cornerstone of cholesterol-lowering therapies,” stressed Dr. Steven Nissen of the Cleveland Clinic, who led the study.

But people who can’t take those proven pills “are very needy patients, they’re extremely difficult to treat,” he said. This option “will have a huge impact on public health.”

Too much so-called LDL or “bad” cholesterol can clog arteries and lead to heart attacks and strokes. Statin pills like Lipitor and Crestor – or their cheap generic equivalents – are the mainstay for lowering LDL cholesterol and preventing heart disease or treating those who already have it. They work by blocking some of the liver’s cholesterol production.

But some people suffer serious muscle pain from statins. While it’s not clear exactly how often that occurs, by some estimates 10% of people who’d otherwise qualify for the pills can’t or won’t take them. They have limited options, including pricey cholesterol-lowering shots and another kind of pill sold as Zetia.

Nexletol also blocks cholesterol production in the liver but in a different way than statins and without that muscle side effect.

The new five-year study tracked nearly 14,000 people who were unable to tolerate more than a very low dose of a statin. Half got daily Nexletol and half a dummy pill.

The main finding: Nexletol-treated patients had a 13% lower risk of a group of major cardiac problems. Then researchers teased apart those different conditions and found a 23% reduced risk of a heart attack, the biggest impact. The drug also cut by 19% procedures to unclog arteries. There wasn’t a difference in deaths, which researchers couldn’t explain but said might require longer to detect.

The data was published in the New England Journal of Medicine and presented Saturday at a meeting of the American College of Cardiology. The study was funded by Nexletol maker Esperion Therapeutics.

The results are “compelling,” Dr. John H. Alexander of Duke University, who wasn’t involved with the study, wrote in the journal. They “will and should” spur use of the drug by patients unwilling or unable to take statins.

“It is premature, however, to consider bempedoic acid as an alternative to statins,” he cautioned. “Given the overwhelming evidence of the vascular benefits,” statins remain the top choice for most patients.

Source: Voice of America