Author: web desk

When COVID-19 hit in 2020, Ghenya Grondin of Waltham, Massachusetts, was a postpartum doula – a person charged with helping young couples navigate the first weeks of their newborn child’s life at home.

Grondin, now aged 44, was infected with SARS-CoV-2 in mid-March of that year – before there were tests, before social distancing or masks, and many months before the medical community recognized long COVID as a complication of COVID-19.

She is part of a community of first-wave long-haulers who faced a new disease without a roadmap or support from the medical establishment.

Three years later, at least 65 million people worldwide are estimated to have long COVID, according to an evidence review published last month in Nature Reviews Microbiology. More than 200 symptoms have been linked to the syndrome – including extreme fatigue, difficulty thinking, headaches, dizziness when standing, sleep problems, chest pain, blood clots, immune dysregulation, and even diabetes.

There are no proven treatments but research is underway.

People infected later in the pandemic had the benefit of vaccination, which “protects at least to some degree” from long COVID, said Dr. Bruce Levy, a Harvard pulmonologist and a co-principal investigator of the National Institute of Health’s $1.15 billion U.S. RECOVER trial, which aims to characterize and find cures for the disease.

“The initial variant of the virus caused a more severe illness than we’re seeing currently in most patients,” he said.

According to the University of Washington’s Institute of Health Metrics and Evaluation, in the first two years of the pandemic women were twice as likely as men to develop long COVID, and 15% of all of those affected at three months continued to experience symptoms beyond 12 months.

An analysis of thousands of health records by the RECOVER trial found that non-Hispanic white women in wealthier areas were more likely than others to have a long COVID diagnosis. Researchers said that likely reflected disparities in access to health care, and suggests that many cases of long COVID among people of color are not being diagnosed.

Grondin grew concerned when she continued to have symptoms three months after her initial infection – but there was no name for it then.

“I just kept saying to my husband, something isn’t right,” she said.

Like her fellow long-haulers, she has experienced a host of symptoms, including fatigue, sleep apnea, pain, cognitive dysfunction, and in her case, a brain aneurysm. She described a frightening moment when she was driving a car with her toddler in the back and had a seizure that left her in the path of oncoming traffic.

She has since been diagnosed with long COVID and can no longer work.

“It just feels like a constant punch in the face,” said Grondin.

Scientists are still working out why some people infected with COVID develop long-term symptoms, but syndromes like this are not new. Other infections such as Lyme disease can result in long-term symptoms, many of which overlap with long COVID.

Leading theories of the root causes of long COVID include the virus or viral proteins remaining in the tissues of some individuals; the infection causing an autoimmune response; or the virus reactivating latent viruses, leading to inflammation that damages tissue.

Kate Porter, 38, of Beverly, Massachusetts, a project manager for a financial services company, believes she was infected on a flight back from Florida in late March of 2020.

She had daily fevers for seven months, muscle weakness, shortness of breath, and excruciating nerve pain.

“I don’t think people realize how brutal physically everything was,” she said. In one of her darker moments, Porter recalled, “I cried on the floor begging for something to take me peacefully. I’ve never been like that.”

Frustrated by the lack of answers from a list of 10 specialists she has seen, Porter has explored alternative medicine. “It has opened me up to other remedies,” she said.

Although her health is much improved now, she still suffers from near daily migraines and neck pain she fears may never go away.

Genie Stevens, 65, a director of climate education, got infected while traveling from her home in Santa Fe to Cape Cod in late March 2020 to visit her mother, and never left. “It completely upended my life,” she said.

She went to an emergency department seeking tests and was told there were none – the typical answer in the spring of 2020, when scientists were scrambling to understand the nature of the virus and tests were being rationed. She was sent home to manage on her own.

A lifelong practitioner of meditation, Stevens took solace there, finding it eased her symptoms.

Confined to her bed that spring, she focused on an ancient crabapple tree outside her room. “I watched every bud unfurl.”

Although largely recovered, Stevens still has flare-ups of brain fog, exhaustion and high-pitched ringing in her ears when she pushes too hard. “This is the astoundingly maddening part of the illness. I feel totally fine, and then bam.”

Source: Voice Of America

The U.N. in Malawi has launched an urgent appeal for aid to deal with the impact of a record cholera outbreak that has so far killed nearly 1,450 people and infected 45,000.

Local health experts say if urgent action isn’t taken to scale up the response, the number of cases could double in the next few months.

The U.N. says the flash appeal seeks to raise $45.3 million to provide life-saving aid to thousands of people in Malawi devastated by the outbreak.

In a statement released Monday, the U.N. said the appeal aims to assist four million people in Malawi, including 56,000 refugees and asylum seekers who are at the highest risk in the outbreak.

The current outbreak started in March last year and has spread to all 29 districts of Malawi.

Rebecca Adda-Dontoh, the U.N. resident coordinator in Malawi, told reporters Monday that more assistance is needed to stop the outbreak.

“So much work has been done but a lot more needs to be done,” she said. “We have focused on health, we have focused on WASH (water, sanitation and hygiene). The two are very important but there are also other sectors like nutrition, protection and even logistics because we need to be able to move supplies from one point to the other.”

Adda-Dontoh said the needed assistance would complement what various donor partners have already contributed.

“The U.N. itself has mobilized already close to $10 million,” she said. “You heard the EU; you heard the U.K. here saying they had already contributed over 500,000 euros for the EU and also over 500,000 pounds for the U.K. Even the government of Malawi is on the ground and already contributed.”

Local media have reported that Malawi needs an additional $40 million for its national plan on cholera response.

Cases of cholera in Malawi have increased since the beginning of January, worsening the country’s largest outbreak in the past two decades.

Malawian President Lazarus Chakwera said last week, when he launched a national anti-cholera campaign, that the country’s health facilities were recording between 500 to 600 cholera cases every day.

The U.N. said that health experts have warned that Malawi could record between 64,000 and 100,000 more cases of cholera within the next three months unless urgent action is taken to scale up the response.

Source: Voice Of America

Botswana has approved the use of injectable anti-retroviral (ARV) drugs to improve adherence to HIV treatment. Minister of Health Edwin Dikoloti says the injections, given every two months, are more convenient than daily pills, which patients sometimes skip.

Health Minister Edwin Dikoloti said the use of injectable ARV medication will start next year, after the recent approval of the drug.

“(The) government is working on introducing the injectable anti-retroviral medication soon. Botswana has, through the professional guidance of the clinical guidelines committee, adopted the use of injectable antiretroviral medicines given every two months, for both prevention and treatment,” said Dikoloti.

Minister Dikoloti said the move will help alleviate concerns that patients are skipping their daily oral dose.

“The injectable ARVs, for both prevention and treatment, will no doubt improve adherence to the HIV treatment in our country. The injectable ARV medication formula comprises cabotegravir and rilpivirine. The cabotegravir injection has already been registered by the Botswana Medicines Regulatory Authority while rilpivirine is still undergoing the registration process,” said Dikoloti.

HIV activist Bonosi Bino Segadimo said the introduction of injectable medication will not only help with compliance but could reduce the stigma associated with the virus that causes AIDS.

“I believe the injectable ARVs will help a lot of people in terms of adherence because a lot of defaulting is caused by taking a pill every day. Some say the bottles (for oral pills) cause a lot of attention when they are in public from their appointments (at health facilities). It’s not that everyone on (ARV) treatment has accepted their status. It is a relief for those who find it hard going around a bottle of medication.”

In 2019, the Botswana Harvard AIDS Institute conducted clinical trials to determine the efficacy of the injectable drug.

The study proved the drug is safe and highly effective for HIV prevention.

Kennedy Mupeli is a programs officer at Center of Youth for Hope, a non-governmental organization that targets young people living with HIV in Botswana.

“We are so excited as activists that HIV medication has actually evolved to this level. Who knows, in the near future this will be taken twice a year. This could also encourage people to test because people have this phobia for daily pills,” said Mupeli.

With the world’s fourth largest prevalence of HIV infections, Botswana becomes the second country in Africa, after South Africa, to adopt the use of the injectable ARV drug.

Source: Voice Of America

Five months after Thailand became the first country in Asia to legalize cannabis, boosters of the hot-button herb are fighting to keep it that way amid mounting calls to re-list the plant as a narcotic.

Cannabis sellers, growers and smokers rallied outside the national government’s headquarters in the capital, Bangkok, Tuesday to discourage authorities from placing the plant back on the country’s controlled narcotics list, with stiff penalties for possession and distribution.

“There is a very high chance that cannabis may end up being illegal again, so it’s quite a very high stake right now,” said Chokwan Chopaka of the People’s Network for Cannabis Legislation in Thailand, which organized the event.

The government’s Narcotics Control Board was meeting Tuesday to discuss concerns about the reported spike in the recreational use of cannabis among adolescents since the plant was legalized in June.

Deputy Prime Minister Wissanu Krea-ngam told reporters Monday that the board would not, and actually could not, re-list cannabis, as some feared.

But threats to the plant’s legal status remain.

Health Minister Anutin Charnvirakul, who championed and approved the delisting, has stood by the move. On November 10, however, a group of physicians and lawmakers petitioned the Administrative Court, which can rule on government decrees, to reverse Anutin’s original order and in effect recriminalize cannabis.

Anutin pushed for legalization by touting the plant’s health benefits and promising to pull struggling farmers out of poverty by turning it into Thailand’s next big cash crop. Cannabis-laced products from cosmetics to ice cream from local producers now line supermarket shelves, and dozens of new dispensaries in Bangkok alone sell pot by the gram from farmers across the country.

Chokwan, who owns a Bangkok dispensary herself and showed up to Tuesday’s rally with free samples for the crowd, said recriminalizing cannabis now would reverse the gains the budding industry has made.

“So many people have come out of poverty because of it, and it’s not because they got a new job or anything like that; it’s because they had ownership [of] the things that they do,” she said.

“Cannabis is one of those things … where you can actually help minimize disparity,” she added. “It gives people like me that extra leg up because I know a bit more than someone who has a lot of money. So, going back illegal again, all this money that has been made legally — I’ve been paying my taxes, everything is all on point — all of that money is going to disappear.”

Natasha Schmahl, an ethnic Thai and cannabis advocate who showed up at the rally with her own sign, said she and her German husband were building what will be the country’s first house made almost entirely of hemp in hopes of inspiring others to do the same. She said recriminalizing the plant would once again rob much of the country of the plant’s health and environmental bounty.

‘Gift from Mother Nature’

“This plant needs to stop being criminalized because it’s a plant and it’s a gift from Mother Nature,” she said. “Of course there need to be rules and regulations around legalization, but to keep it criminalized … and not being able to use the benefits of nature giving us all these medicines is just not helping humanity, and that’s not the way we should move forward.”

It’s the current lack of strict rules and regulations that has critics worried.

The Health Ministry took cannabis off Thailand’s narcotics list before parliament could pass comprehensive legislation clearly defining its legal use, production, sale and import-export. The House of Representatives voted in September to withdraw a bill proposed by Anutin’s Bhumjaithai party so that an ad-hoc committee could keep working on the fine print. Critics of the draft complained that it failed to emphasize medical over recreational use and lacked guardrails to keep cannabis out of the hands of children and adolescents.

Smith Srisont is president of the Forensic Physicians Association of Thailand, which helped spearhead the petition urging the courts to recriminalizing cannabis. He said Thai social media include many videos of students lighting up, and that cases of youngsters being hospitalized for consuming too much have been rising since June.

“Because in Thailand it’s freely to use, the children can use it very easy; this is the problem,” he told VOA by phone. “It can cause psychiatric problems, it can cause depression problem in children, and it can change the brain of children, and it can cause lower IQ in the children … if they use early.”

Srisont also accused the Health Ministry of being disingenuous in its claims to be promoting cannabis for its health benefits alone, a charge the ministry has denied.

“They promote to mix with food, mix with everything. This is recreational, but they lie, they lie that this is medical,” he said. “This is another problem.”

Chokwan, of the People’s Network, believes the reports of adolescents abusing cannabis are being blown out of proportion, especially in the context of underage smoking or drinking rates. As her group’s full name declares, she supports legislation but says recriminalizing cannabis would only drive most users and sellers underground, making the industry harder to control.

Rather than hitting reverse, Chokwan said the government should be doing more to educate the public — adults and adolescents alike — about cannabis, as she does with her own children.

“Cannabis is my business, cannabis is all around my house. My kids does not access it,” she said. “We discuss it, we talk about it, we have conversation around it, and I explain how it’s used, why it’s used, and they don’t want to go anywhere near it because it’s not something that they care for.”

Another vote on the cannabis bill is set for December 7.

Source: Voice Of America

Bacterial infections are the second leading cause of death worldwide, accounting for one in eight of all deaths in 2019, the first global study of their lethality revealed on Tuesday.

The massive new study, published in The Lancet journal, looked at deaths from 33 common bacterial pathogens and 11 types of infection across 204 countries and territories.

The pathogens were associated with 7.7 million deaths — 13.6% of the global total — in 2019, the year before the COVID-19 pandemic took off.

That made them the second-leading cause of death after ischemic heart disease, which includes heart attacks, the study said.

Just five of the 33 bacteria were responsible for half of those deaths: Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae and Pseudomonas aeruginosa.

S. aureus is a bacterium common in human skin and nostrils but behind a range of illnesses, while E. coli commonly causes food poisoning.

The study was conducted under the framework of the Global Burden of Disease, a vast research program funded by the Bill and Melinda Gates Foundation involving thousands of researchers across the world.

“These new data for the first time reveal the full extent of the global public health challenge posed by bacterial infections,” said study co-author Christopher Murray, the director of the U.S.-based Institute for Health Metrics and Evaluation.

“It is of utmost importance to put these results on the radar of global health initiatives so that a deeper dive into these deadly pathogens can be conducted and proper investments are made to slash the number of deaths and infections.”

The research points to stark differences between poor and wealthy regions.

In Sub-Saharan Africa, there were 230 deaths per 100,000 population from the bacterial infections.

That number fell to 52 per 100,000 in what the study called the “high-income super-region” which included countries in Western Europe, North America and Australasia.

The authors called for increased funding, including for new vaccines, to lessen the number of deaths, also warning against “unwarranted antibiotic use.”

Hand washing is among the measures advised to prevent infection.

Source: Voice of America

Forty seven years after he took the stage at Dodger Stadium in Los Angeles in a sequined-studded baseball uniform as the world’s biggest pop star, Elton John walked on to the same stage on Sunday night wearing a bedazzled Dodgers bathrobe, a uniform more fitting for a 75-year-old man on the verge of retirement.

The crowd of more than 50,000 roared at the moment that came in the final minutes of the final North American concert of a tour John says will be his last.

“I want to spend time with my family because I’ll be 76 next year, he said. “I want to bring them out and show you why I’m retiring.”

He embraced and kissed his husband, David Furnish, while his two sons, 11-year-old Zachary and 9-year-old Elijah, wearing matching Dodgers jackets that read “Elton” on the back, waved gleefully at the crowd.

John then broke into “Goodbye Yellow Brick Road,” the inevitable final song that gave the “Farewell Yellow Brick Road” tour its name.

The crowd full of rocket men and rocket women, of blue jean babies and LA ladies, many John’s age but plenty in their 20s and 30s and 40s, swayed and sang along as they had throughout the two-hour show during songs like “Rocket Man” and “Tiny Dancer.” Some wiped away tears.

Many were wearing their own sequins and spangles, sparkling spectacles, top hats, feather boas, and in a few cases, Donald Duck suits, representing stages of John’s 55-year career.

“Thank you all for dressing up,” John said, “it makes me so happy when you wear the most fantastic costumes.”

When that last song ended, John shed the robe and exposed another retirement outfit, a green-and-red tracksuit, and climbed into a small, clear elevator that lifted him into an opening in the backdrop. He could then be seen on a giant video screen walking down a yellow brick road into the distance.

Many others joined John for the occasion.

Kiki Dee took the stage to sing their duet “Don’t Go Breaking My Heart.”

“In 1975, this woman was here with me, and we sang this song,” John said as he brought out Dee. “I asked her to come and recreate that incredible moment.”

John jumped from his usual keyboard spot, grabbed a mic and sang and danced with Dee as his rehearsal piano player Adam Chester pounded the keys in his place.

John played “Don’t Let the Sun Go Down on Me” in tribute to the four bandmates who have died during his career, and after the first verse brought on another guest, shouting, “ladies and gentleman, Brandi Carlile!”

The moment was an unspoken tribute to another late collaborator, George Michael, who dueted with John in the same way on the song in 1991.

Carlile, who was central to Joni Mitchell ‘s recent return to the stage, was wearing her own Dodger-themed spangled suit. She belted out her verses and made a “can you believe this?!” face to the crowd as John put his arm around her and the soaked in the applause.

A drum machine pounded as Dua Lipa, in a black dress that contrasted with the sparkles on everyone else, came out for the first of the encores, “Cold Heart,” her 2021 hit with John.

“I can’t tell you how it feels to be 75 years old and to have the No. 1 record around the world,” John said after. “And this was my very first hit, 52 years ago.”

He started playing piano chords and sang, “It’s a little bit funny, this feeling inside,” the opening line to 1970’s “Your Song.”

“That was your song, Los Angeles!” he shouted after.

About two hours earlier, after taking the stage in a tuxedo with sequins that flared into a flame design and opening the concert with “Benny and the Jets,” he explained the significance of the city to his music.

“All right, this is a very special night for me, a very emotional night for me, and it’s been a long journey, and I first came here to America in 1970 to the City of Angels, Los Angeles, and I played a club called the Troubadour.”

The concert, which streamed live on Disney+, was the last of a three-night stand at the stadium (and his 103rd show in the LA area, he told the crowd). The Farewell Yellow Brick Road tour began in September 2018 with the first of the 300-plus scheduled dates. It was suspended in 2020 because of the COVID pandemic and resumed in 2021.

In January, John heads to Australia and New Zealand, then moves on to Britain and Europe. He’s set to conclude in Sweden in July, though he’s made it clear he is only done traveling, not making music.

Many of those backing him up have been in his band from the start, or very near it, including Nigel Olsson, his drummer since 1969, and Davey Johnstone, his guitarist since 1971, who at age 71 stood at the front of the stage and led the band through a ripping version of “Saturday Night’s Alright for Fighting.”

John also provided a rare on-stage glimpse of an even more long-running collaborator, the man who wrote most of the words the crowd sang along with all night, lyricist Bernie Taupin.

“We’ve been writing together now since 1967,” John said as he hugged Taupin, who could not have contrasted with his writing partner more with his bald head and plain, earth-toned coat. “We still love each other more than we’ve ever done before.”

Source: Voice of America