Category: General

Scientists temporarily attached a pig’s kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use animal organs for lifesaving transplants.

Pigs have been the most recent research focus to address the organ shortage, but among the hurdles: A sugar in pig cells, foreign to the human body, causes immediate organ rejection. The kidney for this experiment came from a gene-edited animal, engineered to eliminate that sugar and avoid an immune system attack.

Surgeons attached the pig kidney to a pair of large blood vessels outside the body of a deceased recipient so they could observe it for two days. The kidney did what it was supposed to do — filter waste and produce urine — and didn’t trigger rejection.

“It had absolutely normal function,” said Dr. Robert Montgomery, who led the surgical team last month at NYU Langone Health in New York. “It didn’t have this immediate rejection that we have worried about.”

This research is “a significant step,” said Dr. Andrew Adams of the University of Minnesota Medical School, who was not part of the work. It will reassure patients, researchers and regulators “that we’re moving in the right direction.”

The dream of animal-to-human transplants, or xenotransplantation, dates to the 17th century with stumbling attempts to use animal blood for transfusions. By the 20th century, surgeons were attempting transplants of organs from baboons into humans, notably Baby Fae, a dying infant, who lived 21 days with a baboon heart.

With no lasting success and much public uproar, scientists turned from primates to pigs, tinkering with their genes to bridge the species gap.

Pigs have advantages over monkeys and apes. They are produced for food, so using them for organs raises fewer ethical concerns. Pigs have large litters, short gestation periods and organs comparable to those of humans.

Pig heart valves also have been used successfully for decades in humans. The blood thinner heparin is derived from pig intestines. Pig skin grafts are used on burns, and Chinese surgeons have used pig corneas to restore sight.

In the NYU case, researchers kept a deceased woman’s body on a ventilator after her family agreed to the experiment. The woman had wished to donate her organs, but they weren’t suitable for traditional donation.

‘Good could come from this’

The family felt “there was a possibility that some good could come from this gift,” Montgomery said.

Montgomery himself received a transplant three years ago, a human heart from a donor with hepatitis C because he was willing to take any organ.

“I was one of those people lying in an ICU waiting and not knowing whether an organ was going to come in time,” he said.

Several biotech companies are in the running to develop suitable pig organs for transplant to help ease the human organ shortage. More than 90,000 people in the U.S. are in line for kidney transplants. Every day, 12 die while waiting.

The advance is a win for Revivicor, a subsidiary of United Therapeutics, the company that engineered the pig and its cousins, a herd of 100 raised in tightly controlled conditions at a facility in Iowa.

The pigs lack a gene that produces alpha-gal, the sugar that provokes an immediate attack from the human immune system.

In December, the Food and Drug Administration approved the gene alteration in the Revivicor pigs as safe for human food consumption and medicine.

But the FDA said developers would need to submit more paperwork before pig organs could be transplanted into living humans.

“This is an important step forward in realizing the promise of xenotransplantation, which will save thousands of lives each year in the not-too-distant future,” said United Therapeutics CEO Martine Rothblatt in a statement.

Experts say tests on nonhuman primates and last month’s experiment with a human body pave the way for the first experimental pig kidney or heart transplants in living people in the next several years.

Raising pigs to be organ donors feels wrong to some people, but it may grow more acceptable if concerns about animal welfare can be addressed, said Karen Maschke, a research scholar at the Hastings Center, who will help develop ethics and policy recommendations for the first clinical trials under a grant from the National Institutes of Health.

“The other issue is going to be: Should we be doing this just because we can?” Maschke said.

Source: Voice of America

U.S. Vice President Kamala Harris said final congressional passage of the Biden administration’s major infrastructure plan comes down to “a fundamental issue” of the lack of water brought on by climate change.

Harris made the comments Monday during a visit to Lake Mead, a man-made reservoir near the gambling and tourist destination city of Las Vegas, Nevada, which provides drinking water and electricity for more than 40 million people across seven western U.S. states and northern Mexico.

The U.S. government in August declared the first-ever water shortage at Lake Mead, which has fallen to record lows amid a two decade-long drought in the Western United States. The shortage has forced officials to impose water rationing next year for Nevada, the neighboring state of Arizona and Mexico.

During the visit, the vice president promoted a $550 billion Infrastructure Investment and Jobs Act, an agreement reached earlier this year between President Joe Biden and a bipartisan group of senators. The investment includes tens of billions of dollars to shore up the nation’s water infrastructure and protect communities against the impact of climate change, including lingering heat waves and droughts, along with investments in water recycling and technology to convert sea water into usable drinking water.

“This is about thinking ahead, recognizing where we are and where we’re headed — if we don’t address these issues with a sense of urgency, understanding this is literally about life,” Harris said.

The infrastructure plan has been approved by the U.S. Senate, but is stalled in the House over intense and increasingly bitter negotiations over funding for the president’s $3.5 trillion Build Back Better plan, which would provide a significant boost to the nation’s social safety net.

Source: Voice of America

Facebook must pay a $4.75 million fine and up to $9.5 million in back pay to eligible victims who say the company discriminated against U.S. workers in favor of foreign ones, the Justice Department announced Tuesday.

The discrimination took place from at least January 1, 2018, until at least September 18, 2019.

The Justice Department said Facebook “routinely refused” to recruit or consider U.S. workers, including U.S. citizens and nationals, asylees, refugees and lawful permanent residents, in favor of temporary visa holders. Facebook also helped the visa holders get their green cards, which allowed them to work permanently

In a separate settlement, the company also agreed to train its employees in anti-discrimination rules and conduct wider searches to fill jobs.

The fines and back pay are the largest civil awards ever given by the DOJ’s civil rights division in its 35-year history.

“Facebook is not above the law and must comply with our nation’s civil rights laws,” Assistant Attorney General Kristen Clarke told reporters in a telephone conference.

“While we strongly believe we met the federal government’s standards in our permanent labor certification [PERM] practices, we’ve reached agreements to end the ongoing litigation and move forward with our PERM program, which is an important part of our overall immigration program,” a Facebook spokesperson said in a statement. “These resolutions will enable us to continue our focus on hiring the best builders from both the U.S. and around the world and supporting our internal community of highly skilled visa holders who are seeking permanent residence.”

Source: Voice of America

As a legal battle plays out in the courts, the Biden administration has asked the U.S. Supreme Court to block a Texas law that bans most abortions in the state.

The Justice Department asked the high court Monday to reverse a decision by an appeals court that allows the law to remain in effect while litigation over the policy continues.

The Republican-backed law bans abortions once cardiac activity has been detected in an embryo, which typically occurs at six weeks, a point when some women are not aware they are pregnant.

The law also allows members of the public to sue people who may have facilitated an abortion after six weeks.

The Supreme Court has already ruled on the issue once before in a lawsuit filed by abortion providers. In a 5-4 vote last month, the court allowed the law to remain in effect as the legal battle over it continues.

The Supreme Court, however, has not yet ruled on the constitutionally of the Texas law.

The high court became more conservative under former President Donald Trump, who appointed three justices to the nine-seat bench. Conservatives now hold a 6-3 majority.

The court’s handling of the abortion issue is being closely watched since it allowed the restrictive Texas law to take effect last month. Later in September, the court announced it would hear arguments in December in a case that directly challenges Roe v. Wade, the decades-old ruling that gives women the right to an abortion.

The court scheduled oral arguments for December 1 to hear a case concerning a Mississippi state law that bans abortions after 15 weeks of pregnancy.

The case asks justices to overturn Roe v. Wade, the 1973 Supreme Court decision that allows women to have abortions in most circumstances. Roe v. Wade establishes a woman’s constitutional right to an abortion before a fetus is viable, typically around 24 weeks of pregnancy.

The court’s latest actions have fueled speculation that a majority of the justices could be inclined to formally curtail abortion rights.

A poll released by Monmouth University last month found that 62% of Americans believe abortion should either always be legal or be legal with some limitations. Twenty-four percent said it should be illegal except in rare circumstances such as rape, while 11% said it should always be illegal.

Source: Voice of America

U.S. Vice President Kamala Harris will travel Monday to Lake Mead to promote the Biden administration’s climate crisis strategy and urge passage of a major infrastructure plan.

The man-made reservoir near the gambling and tourist destination city of Las Vegas, Nevada, is a major source of water for seven Western U.S. states and northern Mexico. Harris will hear from local, state and federal officials on the declining water levels at Lake Mead, the largest in the U.S. by volume, which provides drinking water and electricity for more than 40 million people across the region.

The U.S. government in August declared the first-ever water shortage at Lake Mead, which has fallen to record lows amid a decades-long drought in the Western U.S. The shortage has forced officials to impose water rationing next year for Nevada, the neighboring state of Arizona and Mexico.

With the trip to Lake Mead, Harris plans to promote a $550 billion Infrastructure Investment and Jobs Act, an agreement reached earlier this year between President Joe Biden and a bipartisan group of senators. The investment includes tens of billions of dollars to shore up the nation’s water infrastructure and protect communities against the impact of climate change, including lingering heat waves and droughts.

The infrastructure plan has been approved by the U.S. Senate, but is stalled in the House over intense and increasingly bitter negotiations over funding for the president’s Build Back Better plan, which would provide a significant boost to the nation’s social safety net.

Source: Voice of America

The United Nations announced Monday that a nationwide house-to-house polio vaccination campaign in conflict-torn Afghanistan will recommence next month and hailed the new Taliban government for agreeing to lift a ban on such drives.

Afghanistan is one of two countries in the world, along with neighboring Pakistan, where the highly infectious and incurable disease continues to cripple children.

Officials on both sides documented only one infection each so far in 2021 of the wild poliovirus Type 1 (WPV1), the lowest-ever transmission seen at the same time in Pakistan and Afghanistan, compared to 84 and 56 cases respectively last year.

The house-to-house Afghan anti-polio campaign due to start November 8 is aimed at reaching around 10 million children under the age of 5 across the country, including more than 3 million in remote and previously inaccessible areas, according to the World Health Organization and U.N. children’s agency UNICEF.

The Taliban, who regained power in August, banned door-to-door vaccinations in April 2018 in areas under their control as they waged insurgent attacks against the ousted Western-backed Afghan government and international forces.

“Over this 3-and-a-half-year period, there were approximately 3.3 million children, some of whom could never be reached — or some of them inconsistently reached — with vaccination because of this ban,” Dr. Hamid Jafari, director of polio eradication for the WHO Eastern Mediterranean Region, told VOA.

He explained that the Taliban had seen polio teams’ house-to-house movement as a security risk for their fighters in the wake of the nature of the conflict at the time.

“They have now the controlling authority across the country, and there is not much active conflict right now. So, they (Taliban) have decided to continue their support for polio eradication and specially vaccination through house-to-house vaccination,” the WHO official said.

Jafari recalled the polio eradication program started in Afghanistan in the 1990s when the Taliban were in government and hailed the Islamist group for being supportive of the anti-polio efforts from the outset.

He stressed the need for aggressively implementing the anti-polio campaign, saying the low number of cases offer a “truly unique opportunity” to eradicate the virus from Afghanistan.

Jafari underlined the economic importance of the house-to-house campaign, saying it will be the first major mobilization of Afghan health workers for delivery of a nationwide vaccination service since the Taliban takeover of the country.

“In the current situation of real economic challenges, where many workers and people have not been paid their salaries, this campaign will be one activity in which a large number of the workforce will actually participate in vaccine delivery and will get paid for it,” he said.

WHO officials said a second campaign in Afghanistan, due to begin in coordination with a campaign in Pakistan in December, has also been agreed to.

Jafari cautioned that it is too early for both countries to celebrate that they are nearing polio eradication. He noted there are still several million children in Afghanistan who have not been administered polio drops in recent years, and there are areas in Pakistan where children still need to be inoculated against the virus.

“We have an unprecedented epidemiological opportunity right now to succeed in final polio eradication in both countries. The progress is encouraging, but it is very fragile, and both countries still have to work very hard. This is not a time to be complacent,” Jafari said.

Source: Voice of America