September 29, 2021

Sinocare présente ses produits pour la gestion du diabète et des maladies chroniques lors de la deuxième exposition économique et commerciale Chine-Afrique

CHANGSHA, Chine, 29 septembre 2021 /PRNewswire/ — Sinocare, le leader mondial du développement de tests médicaux, a présenté sa dernière gamme de produits lors de la deuxième exposition économique et commerciale Chine-Afrique (CAETE), qui s’est tenue du 26 au 29 septembre au centre international de congrès et d’expositions de Changsha. Sinocare a présenté, sur le stand qui lui était réservé, différents types de produits pour la gestion des maladies chroniques, notamment le glucomètre, le tensiomètre, le détecteur de lipides sanguins et le détecteur d’acide urique, et a également dévoilé son analyseur multifonction portable analyseur HbA1C portable et son détecteur par fluorescence de produits finis de glycation avancée.

CAETE est une plate-forme importante pour la Chine et les pays africains pour mener une coopération économique et commerciale, et des échanges et dialogues intéressants. Sous le thème « Nouveau départ, nouvelles opportunités, nouvelles réalisations », l’événement de cette année est axé sur les domaines des produits alimentaires et agricoles, des industries médicales et de santé, de la coopération en matière d’infrastructures et de chaînes industrielles, ainsi que de la coopération économique et commerciale approfondie. Sinocare a présenté un certain nombre de produits de pointe qui favoriseront davantage la coopération entre les secteurs médical et de la santé de la Chine et de l’Afrique, et permettront la construction d’une communauté médicale commune.

« Chez Sinocare, notre vision consiste à fournir des produits et des services de haute qualité aux personnes souffrant de diabète et d’autres maladies chroniques afin de les aider à améliorer leur qualité de vie. Nous avons hâte de travailler avec des professionnels de santé et des entreprises privées en Afrique pour fournir à davantage de personnes des solutions accessibles et abordables pour la gestion du diabète », a déclaré Louis Hu, directeur régional de Sinocare pour l’Afrique.

Lors de la CAETE, Sinocare a lancé ses produits phares pour quatre maladies chroniques : le Gold AQ PLUS et le Safe AQ Smart pour la glycémie, l’AES-U111 pour la pression artérielle ; iCARE2100 pour l’analyse multi-index ; et PCH50 pour l’analyse de l’HbA1C. Avec des caractéristiques et des avantages notables, les produits de Sinocare ont attiré l’attention d’innombrables participants qui se sont arrêtés sur le stand pour une consultation.

Gold AQ PLUS possède des propriétés électrochimiques supérieures et une résistance à la corrosion extrêmement importante avec une bandelette de test d’électrode en or pur à 99,99%. Le système est capable de détecter avec précision la température de l’échantillon de sang, le HCT et la température ambiante, et de corriger automatiquement les écarts de résultat. Son autre glucomètre phare exposé était le Safe AQ Smart, doté d’un système FAD-GDH pour des résultats exacts et précis, d’un système d’exploitation facile d’utilisation qui ne nécessite aucun codage et d’une éjection automatique des bandelettes de test.

Pour les patients présentant un taux de cholestérol élevé, le détecteur de lipides et de glycémie à double usage peut être utilisé pour la mesure quantitative du CT, du HDL, des TG et du GLU. Le détecteur a un débit rapide de glucose en 5s et de lipides en 100s, et prend en charge l’impression en ligne par USB et la transmission de données par Bluetooth. Par ailleurs, le système de surveillance de la glycémie et de l’acide urique à double fonction Safe AQ-UG peut être utilisé pour les personnes souffrant de diabète et d’hyperuricémie. Safe AQ UG respecte la norme ISO15197 2013 et est équipé d’une éjection automatique des bandelettes et d’un code intelligent pour les tests d’acide urique.

En outre, iCARE2100 est l’instrument multiplateforme innovant de Sinocare possédant plusieurs indicateurs pour réaliser des tests pratiques au chevet du patient. Alimenté par la technologie principale Liquid Phase iPOCT, iCARE 2100 prend en charge une haute précision et une détection instantanée. Sans utiliser d’autres consommables, les praticiens peuvent réduire les coûts des tests sans compromettre la qualité.

Au-delà de la Chine, Sinocare est présent dans 42 pays d’Afrique, dont l’Algérie, l’Égypte, l’Éthiopie, l’Afrique du Sud et plus encore. L’ensemble de ses ventes à travers le continent ont atteint plus de 110 millions de yuans, les produits les plus populaires de Sinocare étant les systèmes de surveillance de la glycémie, les tensiomètres, les analyseurs de profil lipidique et les détecteurs de HbA1c. La croissance rapide de Sinocare en Afrique s’explique par ses systèmes indolores et faciles à utiliser qui conviennent à un grand nombre de personnes, ainsi que sa stabilité de prélèvement d’échantillons et de bandelette de test avec une technologie brevetée.

Sinocare continue de se développer activement en Afrique et prévoit de créer des usines de production en Algérie et en Égypte pour réaliser la production locale de bandelettes de test de glycémie. Cette initiative réduira considérablement les coûts et le temps de transport, et accélérera ses capacités à fournir aux populations africaines des produits pour la surveillance du diabète.

À propos de Sinocare :

Sinocare compte 19 ans d’expérience dans le secteur des lecteurs de glycémie depuis sa fondation en 2002. La société se consacre au développement, à la production et à la vente de la détection rapide des maladies chroniques grâce à l’utilisation de la technologie des biocapteurs. En 2016, après avoir acquis avec succès Nipro diagnostic Inc. (maintenant renommée Trividia Health Inc.) et PTS Diagnostics Inc., Sinocare est devenu le numéro 5 mondial des fabricants de glucomètres et l’une des principales sociétés au monde d’appareils de test au point de service.

Pour plus d’informations, veuillez consulter le site : www.sinocareintl.com

Facebook : Sinocare In’tl

Contact pour les médias : Echo Gao
Intl_mkt@sinocare.com

Photo – https://mma.prnewswire.com/media/1637313/Sinocare_Headquarters.jpg

September 29, 2021

Adagio Therapeutics Announces New Data Highlighting the Potential of ADG20 for Treatment and Prevention of COVID-19

ADG20 Continues to be Well Tolerated in Healthy Volunteers with Prolonged Half-Life and Serum Virus Neutralization Activity Observed out to Six Months in Ongoing Phase 1 Study

Data from Quantitative Systems Pharmacology/Whole-Body Physiologically Based Pharmacokinetic Modeling Support Evaluation of 300 mg Intramuscular Dose of ADG20 Given as a Single Intramuscular Injection in Ongoing Phase 2/3 Studies

Data to be Presented During IDWeek 2021 and 19^th Annual Discovery on Target Conference

WALTHAM, Mass., Sept. 29, 2021 (GLOBE NEWSWIRE) — Adagio Therapeutics, Inc., (Nasdaq: ADGI) a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential, today announced new data from the company’s COVID-19 antibody program. Updated, six-month data from its ongoing Phase 1 study of ADG20 in healthy participants and data validating the selection of the 300 mg intramuscular (IM) dose given as a single injection that is being evaluated in the company’s ongoing global Phase 2/3 treatment (STAMP) and prevention (EVADE) clinical trials will be presented during four poster sessions at the Infectious Disease Society of America’s IDWeek 2021, being held from Sept. 29 – Oct. 3, 2021. In addition, Adagio’s chief scientific officer, Laura Walker, Ph.D., will present a subset of the ADG20 Phase 1 data as well as background on the identification and optimization of this differentiated antibody clinical candidate in an oral presentation at the 19^th Annual Discovery on Target Conference on Sept. 30, 2021.

“The continued strength of the safety and pharmacokinetic data from our Phase 1 study is encouraging and further underscores the potential impact an antibody like ADG20 – which was designed to be potent, broadly neutralizing and delivered as a single IM injection – could have on people with or at risk of COVID-19,” said Lynn Connolly, M.D., Ph.D., chief medical officer of Adagio. “These Phase 1 data combined with our dose selection strategy, which relied on our innovative modeling approach, have allowed us to initiate and advance our pivotal trials of ADG20 in the treatment and prevention of COVID-19. We anticipate these data will support an Emergency Use Authorization (EUA) application in the first quarter of 2022, which could enable us to bring an important treatment option to patients.”

Phase 1 Trial Update
Adagio is evaluating ADG20 in a Phase 1 randomized, double-blind, placebo-controlled single ascending-dose study to assess safety and tolerability, pharmacokinetics (PK), immunogenicity, and serum virus neutralizing activity of ADG20 ex vivo against SARS-CoV-2. Data from a six-month evaluation timepoint confirmed the extended half-life of ADG20, which approached 100 days based on data from the 300 mg IM dose that was given as a single injection. In addition, 50% serum virus neutralization titers at six months after a 300 mg IM dose of ADG20 were similar to observed peak titers with the mRNA-1273 vaccine and exceeded those achieved with the AZD1222 vaccine series. Importantly, ADG20 was well tolerated with no study drug-related adverse events (AEs), serious AEs, or injection-site or hypersensitivity reactions reported through a minimum of three months follow-up across all cohorts. Participants will continue to be followed through 12 months to assess safety and tolerability, PK, immunogenicity and serum virus neutralizing activity.

Phase 1 Poster Information: (633) Preliminary Results from a Phase 1 Single Ascending-Dose Study Assessing Safety, Serum Viral Neutralizing Antibody Titers (sVNA), and Pharmacokinetic (PK) Profile of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)

Dose Selection Strategy
To support dose selection for Adagio’s global Phase 2/3 STAMP and EVADE clinical trials, the company modified an existing quantitative systems pharmacology whole-body physiologically-based pharmacokinetic (QSP/PBPK) model to better characterize the PK of extended half-life monoclonal antibodies in serum and key sites of viral replication in the respiratory tract. Adagio’s model adequately a priori predicted the observed ADG20 serum PK in non-human primates (NHPs) and humans. The model was further optimized based on data from Adagio’s Phase 1 clinical trial and then applied for dose selection for STAMP and EVADE.

For the STAMP treatment trial, data compiled to date suggest that the 300 mg IM regimen has a projected ability to rapidly achieve and maintain target concentrations at key tissue sites of viral replication, including the ability to attain near complete (> 90%) and durable (> 28-day) SARS-CoV-2 receptor occupancy across a range of baseline viral loads. Further, for the EVADE prevention trial, data compiled to date suggest the 300 mg IM regimen has a projected ability to rapidly exceed target serum concentrations in the majority of simulated patients and to maintain potentially effective concentrations for up to 12 months.

Dose Selection Poster Information

(1086) A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model that a priori Predicts Intramuscular (IM) Pharmacokinetics of ADG20: an Extended Half-life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)
(1089) Use of a Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Prevention of Coronavirus Disease (COVID-19)
(1088) A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment of Coronavirus Disease (COVID-19)

The STAMP and EVADE clinical trials are currently ongoing and enrolling patients globally. For more information, please visit clincialtrials.gov.

About ADG20
ADG20, a monoclonal antibody targeting the spike protein of SARS-CoV-2 and related coronaviruses, is being developed for the prevention and treatment of COVID-19, the disease caused by SARS-CoV-2. ADG20 was designed and engineered to possess high potency and broad neutralization against SARS-CoV-2 and additional clade 1 sarbecoviruses, by targeting a highly conserved epitope in the receptor binding domain. ADG20 displays potent neutralizing activity against the original SARS-CoV-2 strain as well as all known variants of concern. ADG20 has the potential to impact viral replication and subsequent disease through multiple mechanisms of action, including direct blocking of viral entry into the host cell (neutralization) and elimination of infected host cells through Fc-mediated innate immune effector activity. ADG20 is administered by a single intramuscular injection, and was engineered to have a long half-life, with a goal of providing both rapid and durable protection. Adagio is advancing ADG20 through multiple clinical trials on a global basis.

About Adagio Therapeutics
Adagio (Nasdaq: ADGI) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential. The company’s portfolio of antibodies has been optimized using Adimab’s industry-leading antibody engineering capabilities and is designed to provide patients and clinicians with a powerful combination of potency, breadth, durable protection (via half-life extension), manufacturability and affordability. Adagio’s portfolio of SARS-CoV-2 antibodies includes multiple, non-competing broadly neutralizing antibodies with distinct binding epitopes, led by ADG20. Adagio has secured manufacturing capacity for the production of ADG20 with third-party contract manufacturers to support the completion of clinical trials and initial commercial launch. For more information, please visit www.adagiotx.com.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “expects,” “intends,” “projects,” and “future” or similar expressions are intended to identify forward-looking statements. Forward-looking statements include statements concerning, among other things, the timing, progress and results of our preclinical studies and clinical trials of ADG20, including the timing of our planned EUA application, initiation and completion of studies or trials and related preparatory work, the period during which the results of the trials will become available and our research and development programs; our ability to obtain and maintain regulatory approvals for, our product candidates; our ability to identify patients with the diseases treated by our product candidates and to enroll these patients in our clinical trials; our manufacturing capabilities and strategy; and our ability to successfully commercialize our product candidates. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from the results described in or implied by the forward-looking statements, including, without limitation, those risks described under the heading “Risk Factors” in Adagio’s prospectus filed with the Securities and Exchange Commission (“SEC”) on August 6, 2021 and in Adagio’s future reports to be filed with the SEC, including Adagio’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2021. Such risks may be amplified by the impacts of the COVID-19 pandemic. Forward-looking statements contained in this press release are made as of this date, and Adagio undertakes no duty to update such information except as required under applicable law.

Contacts:
Media Contact:
Dan Budwick, 1AB
Dan@1abmedia.com

Investor Contact:
Monique Allaire, THRUST Strategic Communications
monique@thrustsc.com

September 29, 2021

Massive North Sea Wind Farm Could Power Denmark, Neighbors

Weeks before a high-profile climate summit in Glasgow, Scotland, Danish officials are talking up an ambitious program to develop the world’s largest offshore wind energy complex, with the potential to provide enough green energy to power not just Denmark, but some of its neighbors as well.

The complex, to sit on and around an artificial North Sea island about 80 km off Denmark’s coast, would span an area up to the size of 64 soccer fields and support thermal storage facilities, HVDC converters, a heliport, and a research and visitor center.

“You can have hundreds of wind turbines around this island,” said Dan Jorgensen, Denmark’s climate and energy minister, during a visit to Washington this month. His government calculates that the energy island could yield up to 10 gigawatts of electricity — enough for 10 million households.

“Since we’re only 5.8 million people in Denmark, that’s far more electricity than we’ll need for ourselves, so we want to find other countries to be part of this,” Jorgensen said, adding that Denmark is in talks with other European countries.

The 10-gigawatt estimate is at the high end of what might finally be built. Current planning allows for a range of from three to 10 gigawatts, according to Jorgensen. But even at the low end, the energy island would dwarf the largest existing offshore wind farm — Britain’s Walney Extension Offshore Wind Farm in the Irish Sea that has a capacity to generate 0.66 gigawatts and provide power to 600,000 homes.

The world’s largest wind farm of any kind is a 10-gigawatt complex completed this summer and based in the northwestern Gansu province of China. The next largest of any kind is a 1.6-gigawatt wind farm in Jaisalmer, India.

“It’s the biggest infrastructure investment in the history of my country, but we foresee it will be a good business model,” Jorgensen told VOA.

“There will be some initial costs there, but we’re willing to bear them because this will also mean that we will get the project itself, but also the development know-how, the skills, and the expertise that we want.”

The project is remarkable not just for its size but also for its innovative approach to some of the most difficult obstacles to weaning the world off fossil fuels. These include finding an effective way to store energy generated from wind turbines, and a way to transform the electricity into fuels to power transportation systems.

Denmark’s plan is to transform the electricity into hydrogen, which can be used directly as an energy source or turned into fuels for use “in ships, planes and trucks,” as Jorgensen put it.

“This sounds a bit like science fiction, but actually it’s just science; we know how to do it,” he said.

While talks between the Danish government, industry, scientists and potential investors are still in the early stage, one decision has already been made, Jorgensen said.

“We want at least 50.1% of the island to be publicly owned,” he said, calling the island “critical infrastructure because it’ll be such a huge part of our energy supply.” He added that the actual wind turbines will be owned by investors.

“So far we have seen interest from Danish companies and investment funds; we’ve also seen interest from the governments of several European countries. We expect, of course, this will also mean interest from companies from other countries, definitely European, but probably also others.”

Jacob F. Kirkegaard, a Danish economist based in Brussels, says the ambitious plan is plausible in light of Denmark’s track record in developing green energy.

“There are already many days in which Denmark gets all its electrical power from wind energy, so rapid electrification is coming as are further rapid expansions of offshore wind farms,” he told VOA in an exchange of emails.

He said he has “no doubt” that Denmark will achieve full decarbonization by 2050, “probably even considerably before” that date, thanks to broad public support, especially from the young.

According to the Danish embassy in Washington, more than 50% of Denmark’s electrical grid is already powered by wind and solar energy, and the government projects that renewables will meet 100% of the nation’s electricity needs by 2028.

Source: Voice Of America

September 29, 2021

US Proposes 23 Species Be Labeled as Extinct

The U.S. Fish and Wildlife Service said Wednesday that it was proposing 23 species currently protected by the Endangered Species Act be delisted because they are now thought to be extinct.

Perhaps best known among species presumed to be extinct is the Ivory-Billed Woodpecker, a large, colorful and elusive bird with a distinctive call, long sought after by bird-watchers throughout the southeastern United States.

In all, the agency is calling for 11 birds, eight freshwater mussels, two fish, a bat and a plant to be removed from the Endangered Species Act, a measure that went into law in 1973 to provide special protection for species on the brink of extinction.

In a statement on its website, the Fish and Wildlife Service said protection of the 23 species came too late, with most either extinct, functionally extinct, or in steep decline at the timing of listing.

In the statement, U.S. Interior Secretary Deb Haaland, whose department includes the Fish and Wildlife Service, blamed climate change and the loss of natural habitat for pushing those and many other species to the brink of extinction. She said, “Now is the time to lift up proactive, collaborative and innovative efforts to save America’s wildlife.”

U.S. government scientists do not declare extinctions casually. It often takes decades of fruitless searching. About half of the species in this group were already considered extinct by the Switzerland-based International Union for Conservation of Nature, the global authority on the status of animals and plants.

Officials with the Fish and Wildlife Service tend to move more slowly, in part because it is working through a backlog, but also to exhaust all efforts to follow up on reports of sightings.

In the case of the Ivory-Billed Woodpecker, there have been numerous unconfirmed reports of both sightings of the large, colorful red, white and black bird with a large beak and head feathers, and of hearing its distinctive call in the woods.

The IUCN is reportedly not putting the woodpecker on its extinction list because the organization believes the bird may still exist in parts of Cuba.

Source: Voice Of America